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Bo-Ruei Chen


EDUCATION

09/2016 - 07/2018 ; National Taiwan University

● GPA: 4.00
● Thesis Topic: Design and Synthesis of Thioflavin-Conjugate for                                           Therapy of Alzheimer’s Disease  

● Advisor: Fang, Jim-Min、Tsai, Yeun-Min (Co-Advisor) 

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09/2012 - 06/2016 ; National Taiwan Normal University

● GPA: 3.37
● Seminar Topic: Cytoprotective and anti-inflammatory effects of                                             PAL31 overexpression in glial cells 

● Advisor: Cheng, Hen-Rich 

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01/2020- 03/2020 ; Cebu Globalization ESL Center

● Course Type : Premier Sparta Course

● Daily 12H Class : 1:1 class(5H) + 1:4 class(3H) + Evening class 

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INTERNSHIP

05/2018 - 09/2018 ; Research Assistant

Genomics Research Center, Academia Sinica
● Established a systematic chemical synthesis method.
● Participated in a patent package application project.
● Engaged with scholars from different fields and organized the meetings and published reports.
● Instructed juniors in the operation and maintenance of systems and instruments.

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03/2014 - 09/2014 ; Researcher

Dept. and Institute of Pharmacology, National Yang-Ming University

● Designed bio-compatible materials for animal experiments.

● Operated animals, cell experiments, and organized and wrote detailed experimental data.

● Assisted publishing papers in celebrated Biomedical Science Journal.

● Checked and approved operational quality of lab equipment. 
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SUBSTITUTE MILITARY SERVICE 

08/2018 - 08/2019 ; Class President

● Serviced as the group leader and managed the substitute military service affairs on the year.

● Maintained security in the camp, and managed the registration issue.

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EXCHANGE STUDENT

07/2017 - 10/2017 ; DAAD-MOST Lab Exchange Student 

Optimized the chemical reaction of Terpene Cyclization. 

Provided a more effective synthetic route to commercially available drugs and new materials. 

● Optimized the product yield and tool performance to meet process and integration requirements.

● Provided supervisor substantial supports through the performance of overseeing any necessary diagnoses, troubleshooting, service.
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EXTRACURRICULAR ACTIVITIES

09/2014 - 09/2015 ; Director

Youth Elementary School, Youth Volunteers Winter Camp

 Instructed nearly 100 impoverished students in the school to learn science and design educational and intriguing experiments.

 Provided free service and saved $100,000 for the local school.

● Received a certificate of appreciation and an contribution award. 

● Worked closely with teams and customers (school, sponsors).
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10/2012 - 10/2014 ; Vice President

Dept. of Chemistry Student Association, NTNU University 

 Won an award of Best Weekly-Series Award.

● Doubled the number of students in the department.
● Integrated group opinions and designed a campaign to sell $25,000.

● Cooperated closely with team members and school administration organization.
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09/2012-09/2015 ; Event Coordinator

Taipei Keelung Alumni Association
Be hired as a consultant and annual cadre to assist the club.
● Implemented activities to attract freshmen to join the club.

 Organized 12 events and managed nearly 100 members in 3 years.
● Won an award of Best Member Award and Best Promotion Award.

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AWARDS

09/2017, Exchange Student Program Candidate 

(1/82), University of Hamburg, Germany

07/2017, People’s Choice Award 

(2/55), Dept. of Chemistry, NTU University, Taiwan

03/2017, Students’ Choice Award

(2/80), Dept. of Chemistry, NTU University, Taiwan

SKILLS


Languages  

 Chinese (Native) 

● English (B2+) 

● German (A1) 

● Taiwanese (Native)


Certificate

● CMP Metrology

● Photolithography 

● Etching

● Semiconductor Devices Physics

●TOEFL https://reurl.cc/1VqEQ


Tools 

 ChemDraw

 ChemBio 3D Ultra

 Scifinder

 Reaxys

Statistical Process Control
 PowerDirector

MASTER THESIS

Projects 01 00@2x

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease. My research aim is to introduce an appropriate linker for conjugation of the above-mentioned critical compounds. Since thioflavin-T is an amyloid binder, and lenalidomide is a known ubiquitin binder, the conjugated product may initiate ubiquitination to degrade amyloid protein. In this way, the conjugate compound incorporating an appropriate linker can attain the desired lipophilicity without severe steric hindrance to binding amyloid and ubiquitin E3 ligase. 

Paper

● Designed bio-materials for animal experiments.
● Operated animals, cell experiments and organized experimental data.
● Assisted in publishing papers in the celebrated Journal of Biomedical Science.
Provided doctors and patients support such as troubleshooting, experiment trial.

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ACS Poster

● Cooperated closely with experts to optimize product performance and meet drug processes and customer requirements.
● Analyzed and integrated complete experimental data.
● Operated cells, animal experiments and verified feasibility.
● Designed and synthesized a range of drugs for the treatment of Alzheimer's disease.


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